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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
12.12
Human Site:
S424
Identified Species:
20.51
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S424
K
S
N
S
F
F
P
S
E
T
R
K
D
K
V
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S424
K
S
N
S
F
F
P
S
E
T
R
K
D
K
V
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S424
K
S
S
S
F
F
P
S
E
T
R
K
D
K
V
Dog
Lupus familis
XP_534917
565
65190
L468
Q
T
L
R
K
P
S
L
C
L
P
S
E
A
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
A535
Q
I
L
R
K
P
G
A
S
I
S
S
E
I
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
K480
K
R
G
P
P
G
S
K
D
W
A
A
A
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
T371
E
G
F
P
K
H
I
T
N
H
K
G
I
T
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
D429
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
Frog
Xenopus laevis
Q2TAE3
750
84138
A562
P
G
W
T
V
P
E
A
P
T
Q
V
T
I
E
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
E532
K
E
S
D
N
N
Y
E
F
T
Y
R
K
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S518
S
S
S
S
G
L
N
S
V
S
Q
K
S
S
C
Honey Bee
Apis mellifera
XP_396369
614
68978
N500
S
T
V
N
A
N
T
N
A
N
A
T
S
M
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
E305
L
E
H
L
A
M
M
E
R
A
L
G
P
L
P
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
P689
G
G
V
L
N
L
N
P
L
E
R
W
T
P
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
0
6.6
N.A.
0
0
6.6
13.3
N.A.
26.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
20
13.3
N.A.
20
13.3
26.6
26.6
N.A.
46.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
15
0
0
15
8
8
15
8
8
15
0
% A
% Cys:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
8
% C
% Asp:
0
0
0
8
0
0
0
8
15
0
0
0
22
8
0
% D
% Glu:
8
15
0
0
0
0
8
15
22
8
0
0
15
0
15
% E
% Phe:
0
0
8
0
22
22
0
0
8
0
0
8
0
0
8
% F
% Gly:
15
22
8
0
8
15
8
0
0
0
0
15
0
0
0
% G
% His:
0
0
8
0
0
8
0
0
0
8
0
0
0
0
8
% H
% Ile:
0
8
0
0
0
0
8
0
0
8
0
0
8
15
0
% I
% Lys:
36
0
0
0
29
0
0
8
0
0
8
29
8
22
8
% K
% Leu:
8
0
15
22
0
15
0
8
8
8
15
0
8
15
0
% L
% Met:
0
0
0
0
0
8
8
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
15
8
15
15
15
8
8
8
0
0
0
0
0
% N
% Pro:
8
0
0
15
8
22
22
8
8
8
8
0
8
8
8
% P
% Gln:
15
0
0
0
0
0
0
0
0
0
15
0
0
0
15
% Q
% Arg:
0
8
0
15
0
0
0
0
8
0
29
8
0
0
0
% R
% Ser:
15
29
22
29
0
0
15
29
8
8
8
15
15
8
8
% S
% Thr:
0
15
0
8
0
0
8
8
0
36
0
8
15
8
8
% T
% Val:
0
0
15
0
8
0
0
0
8
0
0
8
0
0
22
% V
% Trp:
0
0
8
0
0
0
0
0
0
8
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _